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By Sharma S Prabhakar
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Bondar, et al. (2010). " N Engl J Med 363(4): 343-54. Pickering, M. , H. T. Cook, et al. (2002). " Nat Genet 31(4): 424-8. Pippin, J. , R. Durvasula, et al. (2003). " J Clin Invest 111(6): 877-85. , T. H. Winkler, et al. (1996). " J Exp Med 184(3): 853-61. , E. I. Prodromidi, et al. (2005). " J Am Soc Nephrol 16(5): 1350-9. Reynolds, J. and C. D. Pusey (2001). " J Am Soc Nephrol 12(1): 61-70. Ring, G. , Z. Dai, et al. (1999). " J Immunol 163(4): 2243-8. Rodriguez-Iturbe, B. and S. Batsford (2007).
Tau-crystallin/alpha-enolase: one gene encodes both an enzyme and a lens structural protein. J Cell Biol, Vol. 107, No. 6 Pt 2, (Dec 1988), pp. 2729-2736, ISSN 0021-9525 3 Anti-Complement Autoantibodies in Membranoproliferative Glomerulonephritis and Dense Deposit Disease Mihály Józsi Junior Research Group Cellular Immunobiology, Leibniz Institute for Natural Product Research and Infection Biology, Jena Germany 1. Introduction The complement system is an essential part of innate immunity by its role in protection against infections, but it is also involved in waste disposal and in modulating the adaptive immune response.
2010; Debiec & Ronco, 2011; Hofstra, et al. 2011). A correlation of autoantibodies level with proteinuria has been proposed, suggesting that high circulating titers are in relationship with phases of immunological activity of the disease. A strong association with clinical outcome is still lacking. It is also an important issue to establish a correlation among antibodies against different antigens; such stuidies are on the way. Probably they will help in establishing a hierarchy between antigens, if it exists.